Effects of Leptin Replacement Therapy on Pancreatic b-Cell Function in Patients With Lipodystrophy
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چکیده
In a prospective, open-label, currently ongoing study we studied the effects of leptin replacement on b-cell function in 13 patients with congenital or acquired lipodystrophy. Insulin secretory rate (ISR) was calculated by C-peptide deconvolution from plasma glucose and C-peptide levels measured during oral glucose tolerance tests (OGTTs) performed at baseline and after 16–20 weeks of leptin replacement. b-Cell glucose sensitivity and rate sensitivity were assessed by mathematical modeling of OGTT.
منابع مشابه
Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy
OBJECTIVE Leptin administration is known to directly modulate pancreatic β-cell function in leptin-deficient rodent models. However, human studies examining the effects of leptin administration on β-cell function are lacking. In this study, we examined the effects (16-20 weeks) of leptin replacement on β-cell function in patients with lipodystrophy. RESEARCH DESIGN AND METHODS In a prospective,...
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تاریخ انتشار 2014